Natural organic matter does not diminish the mammalian bioavailability of 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Identifieur interne : 000102 ( Main/Exploration ); précédent : 000101; suivant : 000103Natural organic matter does not diminish the mammalian bioavailability of 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Auteurs : Qi Yuan [États-Unis] ; J Brett Sallach [Royaume-Uni] ; Geoff Rhodes [États-Unis] ; Anthony Bach [États-Unis] ; Robert Crawford [États-Unis] ; Hui Li [États-Unis] ; Cliff T. Johnston [États-Unis] ; Brian J. Teppen [États-Unis] ; Norbert E. Kaminski [États-Unis] ; Stephen A. Boyd [États-Unis]Source :
- Chemosphere [ 1879-1298 ] ; 2020.
Abstract
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a toxic and persistent organic pollutant found in soils and sediments. It has been linked to several adverse health outcomes in humans and wildlife, including suppression of the immune system. TCDD is strongly sorbed to soils/sediments due to its extremely low water solubility. Presently, the bioavailability of soil/sediment-sorbed TCDD to mammals is not completely understood. Our previous studies demonstrated that TCDD adsorbed to representative inorganic geosorbents (i.e. porous silica and smectite clay) exhibited the same bioavailability to mice as TCDD dissolved in corn oil, whereas sequestration by activated carbons eliminated TCDD bioavailability. In this study, we evaluated the effects of amorphous natural organic matter (NOM), primarily in the form of aquatic humic and fulvic acids, on the mouse bioavailability of TCDD. An aqueous suspension of TCDD mixed with NOM was administered to mice via oral gavage. The relative bioavailability of TCDD was assessed by two sensitive aryl hydrocarbon receptor-mediated responses in mice: 1) hepatic induction of cyp1A1 mRNA; and 2) suppression of immunoglobulin M (IgM) antibody-forming cell (AFC) response which is an indicator of immunotoxicity. Hepatic induction of cyp1A1 mRNA and suppression of IgM AFC induced by TCDD were similar in the NOM-sorbed form and dissolved in corn oil, revealing no loss of bioavailability when associated with NOM. Hence, NOM-associated TCDD is as capable of suppressing humoral immunity in mice as TCDD dissolved in corn oil, indicating that NOM-sorbed TCDD is likely to fully retain its bioavailability to mammals and, by inference, humans.
DOI: 10.1016/j.chemosphere.2020.128420
PubMed: 33032214
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Electronic address: brett.sallach@york.ac.uk.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Environment and Geography, University of York, Heslington, York, YO10 5NG</wicri:regionArea><wicri:noRegion>YO10 5NG</wicri:noRegion></affiliation></author><author><name sortKey="Rhodes, Geoff" sort="Rhodes, Geoff" uniqKey="Rhodes G" first="Geoff" last="Rhodes">Geoff Rhodes</name><affiliation wicri:level="4"><nlm:affiliation>Department of Plant, Soil, and Microbial Sciences, Michigan State University, East Lansing, MI, 48824, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Plant, Soil, and Microbial Sciences, Michigan State University, East Lansing, MI, 48824</wicri:regionArea><orgName type="university">Université d'État du Michigan</orgName><placeName><settlement type="city">East Lansing</settlement><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Bach, Anthony" sort="Bach, Anthony" uniqKey="Bach A" first="Anthony" last="Bach">Anthony Bach</name><affiliation wicri:level="4"><nlm:affiliation>Institute for Integrative Toxicology, Michigan State University, East Lansing, MI, 48824, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Integrative Toxicology, Michigan State University, East Lansing, MI, 48824</wicri:regionArea><orgName type="university">Université d'État du Michigan</orgName><placeName><settlement type="city">East Lansing</settlement><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Crawford, Robert" sort="Crawford, Robert" uniqKey="Crawford R" first="Robert" last="Crawford">Robert Crawford</name><affiliation wicri:level="4"><nlm:affiliation>Institute for Integrative Toxicology, Michigan State University, East Lansing, MI, 48824, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Integrative Toxicology, Michigan State University, East Lansing, MI, 48824</wicri:regionArea><orgName type="university">Université d'État du Michigan</orgName><placeName><settlement type="city">East Lansing</settlement><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Li, Hui" sort="Li, Hui" uniqKey="Li H" first="Hui" last="Li">Hui Li</name><affiliation wicri:level="4"><nlm:affiliation>Department of Plant, Soil, and Microbial Sciences, Michigan State University, East Lansing, MI, 48824, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Plant, Soil, and Microbial Sciences, Michigan State University, East Lansing, MI, 48824</wicri:regionArea><orgName type="university">Université d'État du Michigan</orgName><placeName><settlement type="city">East Lansing</settlement><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Johnston, Cliff T" sort="Johnston, Cliff T" uniqKey="Johnston C" first="Cliff T" last="Johnston">Cliff T. Johnston</name><affiliation wicri:level="1"><nlm:affiliation>Crop, Soil, and Environmental Science, Purdue University, West Lafayette, IN, 47907, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Crop, Soil, and Environmental Science, Purdue University, West Lafayette, IN, 47907</wicri:regionArea><wicri:noRegion>47907</wicri:noRegion></affiliation></author><author><name sortKey="Teppen, Brian J" sort="Teppen, Brian J" uniqKey="Teppen B" first="Brian J" last="Teppen">Brian J. Teppen</name><affiliation wicri:level="4"><nlm:affiliation>Department of Plant, Soil, and Microbial Sciences, Michigan State University, East Lansing, MI, 48824, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Plant, Soil, and Microbial Sciences, Michigan State University, East Lansing, MI, 48824</wicri:regionArea><orgName type="university">Université d'État du Michigan</orgName><placeName><settlement type="city">East Lansing</settlement><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Kaminski, Norbert E" sort="Kaminski, Norbert E" uniqKey="Kaminski N" first="Norbert E" last="Kaminski">Norbert E. Kaminski</name><affiliation wicri:level="4"><nlm:affiliation>Institute for Integrative Toxicology, Michigan State University, East Lansing, MI, 48824, USA; Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, 48824, USA; Center for Research on Ingredient Safety, Michigan State University, East Lansing, MI, 48824, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Integrative Toxicology, Michigan State University, East Lansing, MI, 48824, USA; Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, 48824, USA; Center for Research on Ingredient Safety, Michigan State University, East Lansing, MI, 48824</wicri:regionArea><orgName type="university">Université d'État du Michigan</orgName><placeName><settlement type="city">East Lansing</settlement><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Boyd, Stephen A" sort="Boyd, Stephen A" uniqKey="Boyd S" first="Stephen A" last="Boyd">Stephen A. Boyd</name><affiliation wicri:level="4"><nlm:affiliation>Department of Plant, Soil, and Microbial Sciences, Michigan State University, East Lansing, MI, 48824, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Plant, Soil, and Microbial Sciences, Michigan State University, East Lansing, MI, 48824</wicri:regionArea><orgName type="university">Université d'État du Michigan</orgName><placeName><settlement type="city">East Lansing</settlement><region type="state">Michigan</region></placeName></affiliation></author></analytic><series><title level="j">Chemosphere</title><idno type="eISSN">1879-1298</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a toxic and persistent organic pollutant found in soils and sediments. It has been linked to several adverse health outcomes in humans and wildlife, including suppression of the immune system. TCDD is strongly sorbed to soils/sediments due to its extremely low water solubility. Presently, the bioavailability of soil/sediment-sorbed TCDD to mammals is not completely understood. Our previous studies demonstrated that TCDD adsorbed to representative inorganic geosorbents (i.e. porous silica and smectite clay) exhibited the same bioavailability to mice as TCDD dissolved in corn oil, whereas sequestration by activated carbons eliminated TCDD bioavailability. In this study, we evaluated the effects of amorphous natural organic matter (NOM), primarily in the form of aquatic humic and fulvic acids, on the mouse bioavailability of TCDD. An aqueous suspension of TCDD mixed with NOM was administered to mice via oral gavage. The relative bioavailability of TCDD was assessed by two sensitive aryl hydrocarbon receptor-mediated responses in mice: 1) hepatic induction of cyp1A1 mRNA; and 2) suppression of immunoglobulin M (IgM) antibody-forming cell (AFC) response which is an indicator of immunotoxicity. Hepatic induction of cyp1A1 mRNA and suppression of IgM AFC induced by TCDD were similar in the NOM-sorbed form and dissolved in corn oil, revealing no loss of bioavailability when associated with NOM. Hence, NOM-associated TCDD is as capable of suppressing humoral immunity in mice as TCDD dissolved in corn oil, indicating that NOM-sorbed TCDD is likely to fully retain its bioavailability to mammals and, by inference, humans.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">33032214</PMID><DateRevised><Year>2020</Year><Month>10</Month><Day>28</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1879-1298</ISSN><JournalIssue CitedMedium="Internet"><Volume>264</Volume><Issue>Pt 1</Issue><PubDate><Year>2020</Year><Month>Sep</Month><Day>23</Day></PubDate></JournalIssue><Title>Chemosphere</Title><ISOAbbreviation>Chemosphere</ISOAbbreviation></Journal><ArticleTitle>Natural organic matter does not diminish the mammalian bioavailability of 2,3,7,8-tetrachlorodibenzo-p-dioxin.</ArticleTitle><Pagination><MedlinePgn>128420</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0045-6535(20)32615-1</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.chemosphere.2020.128420</ELocationID><Abstract><AbstractText>2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a toxic and persistent organic pollutant found in soils and sediments. It has been linked to several adverse health outcomes in humans and wildlife, including suppression of the immune system. TCDD is strongly sorbed to soils/sediments due to its extremely low water solubility. Presently, the bioavailability of soil/sediment-sorbed TCDD to mammals is not completely understood. Our previous studies demonstrated that TCDD adsorbed to representative inorganic geosorbents (i.e. porous silica and smectite clay) exhibited the same bioavailability to mice as TCDD dissolved in corn oil, whereas sequestration by activated carbons eliminated TCDD bioavailability. In this study, we evaluated the effects of amorphous natural organic matter (NOM), primarily in the form of aquatic humic and fulvic acids, on the mouse bioavailability of TCDD. An aqueous suspension of TCDD mixed with NOM was administered to mice via oral gavage. The relative bioavailability of TCDD was assessed by two sensitive aryl hydrocarbon receptor-mediated responses in mice: 1) hepatic induction of cyp1A1 mRNA; and 2) suppression of immunoglobulin M (IgM) antibody-forming cell (AFC) response which is an indicator of immunotoxicity. Hepatic induction of cyp1A1 mRNA and suppression of IgM AFC induced by TCDD were similar in the NOM-sorbed form and dissolved in corn oil, revealing no loss of bioavailability when associated with NOM. Hence, NOM-associated TCDD is as capable of suppressing humoral immunity in mice as TCDD dissolved in corn oil, indicating that NOM-sorbed TCDD is likely to fully retain its bioavailability to mammals and, by inference, humans.</AbstractText><CopyrightInformation>Copyright © 2020 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Yuan</LastName><ForeName>Qi</ForeName><Initials>Q</Initials><AffiliationInfo><Affiliation>Department of Microbiology and Immunology, Creighton University, Omaha, NE, 68178, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sallach</LastName><ForeName>J Brett</ForeName><Initials>JB</Initials><AffiliationInfo><Affiliation>Department of Environment and Geography, University of York, Heslington, York, YO10 5NG, United Kingdom. Electronic address: brett.sallach@york.ac.uk.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rhodes</LastName><ForeName>Geoff</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Plant, Soil, and Microbial Sciences, Michigan State University, East Lansing, MI, 48824, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bach</LastName><ForeName>Anthony</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institute for Integrative Toxicology, Michigan State University, East Lansing, MI, 48824, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Crawford</LastName><ForeName>Robert</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Institute for Integrative Toxicology, Michigan State University, East Lansing, MI, 48824, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Hui</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Plant, Soil, and Microbial Sciences, Michigan State University, East Lansing, MI, 48824, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Johnston</LastName><ForeName>Cliff T</ForeName><Initials>CT</Initials><AffiliationInfo><Affiliation>Crop, Soil, and Environmental Science, Purdue University, West Lafayette, IN, 47907, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Teppen</LastName><ForeName>Brian J</ForeName><Initials>BJ</Initials><AffiliationInfo><Affiliation>Department of Plant, Soil, and Microbial Sciences, Michigan State University, East Lansing, MI, 48824, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kaminski</LastName><ForeName>Norbert E</ForeName><Initials>NE</Initials><AffiliationInfo><Affiliation>Institute for Integrative Toxicology, Michigan State University, East Lansing, MI, 48824, USA; Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, 48824, USA; Center for Research on Ingredient Safety, Michigan State University, East Lansing, MI, 48824, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Boyd</LastName><ForeName>Stephen A</ForeName><Initials>SA</Initials><AffiliationInfo><Affiliation>Department of Plant, Soil, and Microbial Sciences, Michigan State University, East Lansing, MI, 48824, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>09</Month><Day>23</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Chemosphere</MedlineTA><NlmUniqueID>0320657</NlmUniqueID><ISSNLinking>0045-6535</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Amorphous natural organic matter</Keyword><Keyword MajorTopicYN="N">Bioavailability</Keyword><Keyword MajorTopicYN="N">TCDD</Keyword></KeywordList><CoiStatement>Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>05</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>08</Month><Day>21</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>09</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>10</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>10</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>10</Month><Day>8</Day><Hour>20</Hour><Minute>19</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">33032214</ArticleId><ArticleId IdType="pii">S0045-6535(20)32615-1</ArticleId><ArticleId IdType="doi">10.1016/j.chemosphere.2020.128420</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Michigan</li></region><settlement><li>East Lansing</li></settlement><orgName><li>Université d'État du Michigan</li></orgName></list><tree><country name="États-Unis"><noRegion><name sortKey="Yuan, Qi" sort="Yuan, Qi" uniqKey="Yuan Q" first="Qi" last="Yuan">Qi Yuan</name></noRegion><name sortKey="Bach, Anthony" sort="Bach, Anthony" uniqKey="Bach A" first="Anthony" last="Bach">Anthony Bach</name><name sortKey="Boyd, Stephen A" sort="Boyd, Stephen A" uniqKey="Boyd S" first="Stephen A" last="Boyd">Stephen A. Boyd</name><name sortKey="Crawford, Robert" sort="Crawford, Robert" uniqKey="Crawford R" first="Robert" last="Crawford">Robert Crawford</name><name sortKey="Johnston, Cliff T" sort="Johnston, Cliff T" uniqKey="Johnston C" first="Cliff T" last="Johnston">Cliff T. Johnston</name><name sortKey="Kaminski, Norbert E" sort="Kaminski, Norbert E" uniqKey="Kaminski N" first="Norbert E" last="Kaminski">Norbert E. Kaminski</name><name sortKey="Li, Hui" sort="Li, Hui" uniqKey="Li H" first="Hui" last="Li">Hui Li</name><name sortKey="Rhodes, Geoff" sort="Rhodes, Geoff" uniqKey="Rhodes G" first="Geoff" last="Rhodes">Geoff Rhodes</name><name sortKey="Teppen, Brian J" sort="Teppen, Brian J" uniqKey="Teppen B" first="Brian J" last="Teppen">Brian J. Teppen</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Sallach, J Brett" sort="Sallach, J Brett" uniqKey="Sallach J" first="J Brett" last="Sallach">J Brett Sallach</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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